New Microscope for Laser Capture Microdissection (LMD) clinical proteomics and array scanning

Aalborg University (AAU) aims to acquire a versatile Laser capture MicroDissection (LMD) system to enable clinical and life science workflows in spatial proteomics, transcriptomics, and multi-omics from cells, soft tissue to robust tissues (tendon, bone). The main ambition is to expand their analytical capabilities in the field of deep visual …

CPV: 38000000 Laborgeräte, optische Geräte und Präzisionsgeräte (außer Gläser)
Ausführungsort:
New Microscope for Laser Capture Microdissection (LMD) clinical proteomics and array scanning
Vergabestelle:
Aalborg Universitet
Vergabenummer:
2025-132-00690

1. Buyer

1.1 Buyer

Official name : Aalborg Universitet

2. Procedure

2.1 Procedure

Title : New Microscope for Laser Capture Microdissection (LMD) clinical proteomics and array scanning
Description : Aalborg University (AAU) aims to acquire a versatile Laser capture MicroDissection (LMD) system to enable clinical and life science workflows in spatial proteomics, transcriptomics, and multi-omics from cells, soft tissue to robust tissues (tendon, bone). The main ambition is to expand their analytical capabilities in the field of deep visual proteomics (DVP) by Mass Spectrometry using a wide range of biological specimens. The instrument will be used for running low to medium scale spatial DVP experiments and implementing single-cell to regional tissue multi-omics experimental workflows and supporting spatial RNA sequencing experiments. Furthermore, cell manipulation or isolation of single-cells in suspension is an future request. The multicolor (>4 filter) options will be applied to protein array scanning at high spatial resolution. The combined system for laser microdissection (MMI CellCut) and Whole Slide Imaging (MMI CellScan) as well as MMI CellRobot is distributed by Molecular Machines and Industries GmbH and is the only versatile LMD system on the market that encompassing all the required features. The MMI CellScan is a cutting-edge whole slide scanner designed to convert any sample format into high-resolution digital data in 5 dimensions. It offers time-lapse imaging for dynamic studies, Z-stack scanning to capture depth, XY scanning for full-slide coverage, and multi-color fluorescence for comprehensive molecular insights. The versability of the CellScan allows imaging of non-tissue speciments such as protein array slides. The MMI CellCut is the most gentle laser microdissection system on the market, designed to protect the surrounding area and preserve the biological integrity of the cut sample. This precision enables reproducible and meaningful results in Deep Visual Proteomics (DVP) experiments and other research applications. The system achieves gentle cutting using a low-energy laser (pulse energy <= 2 µJ), ensuring that tissue remains undamaged. Despite the low energy, the laser operates with a high pulse rate (4 kHz), providing sufficient energy to cut even thicker tissue samples. In addition, the CellCut system offers a serial cutting function for three-point shape and position annotations and a z-drill function that allows wet and thicker tissue areas to be cut step by step with a definable z-step size. This combination delivers the best cutting performance on the market, with a very precise cutting edge of 0.3 µm. Moreover, MMI is the only supplier whose system moves the stage rather than the laser during the cutting procedure. This innovative approach keeps the laser consistently in optimal focus, enhancing cutting efficiency and precision. The MMI CellCut enables leading live cell-cutting ability to culture, dissect and isolate live cells, also in fluorescence mode. In contrast to systems that uses an upright microscope, the MMI laser comes from below, allowing for the dissection of living cells within live-cell chambers or 18-well membrane slides without the need to remove the culture media. This ensures the highest cell integrity for meaningful proteomics applications and re-cultivation. The process is contamination-free, as there is no need to open the culture dish, unlike alternative LMD systems. Additionally, the CellCut LMD system can be combined with a climate chamber offering full environmental control to maintain optimal conditions during the process. Based on a completed market analysis, Aalborg University assesses that, due to the technical reasons mentioned above, only one supplier can meet the total delivery. For those technical reasons, the contract will awarded without prior publication of a tender announcement in accordance with the section §80(3)(2) of the Danish Public Procurement Act. The contract will not be concluded until after expiry of standstill period of 10 calendar days, calculated from the day on which the Direct award preannouncement is Published.
Procedure identifier : 01a397b9-ebd1-4042-8298-c7222c7fd676
Internal identifier : 2025-132-00690
Type of procedure : Negotiated without prior call for competition

2.1.1 Purpose

Main nature of the contract : Supplies
Main classification ( cpv ): 38000000 Laboratory, optical and precision equipments (excl. glasses)

2.1.2 Place of performance

Postal address : Niels Jernes Vej 10
Town : Aalborg Øst
Postcode : 9220
Country subdivision (NUTS) : Nordjylland ( DK050 )
Country : Denmark

2.1.4 General information

Legal basis :
Directive 2014/24/EU

5. Lot

5.1 Lot technical ID : LOT-0000

Title : New Microscope for Laser Capture Microdissection (LMD) clinical proteomics and array scanning
Description : Aalborg University (AAU) aims to acquire a versatile Laser capture MicroDissection (LMD) system to enable clinical and life science workflows in spatial proteomics, transcriptomics, and multi-omics from cells, soft tissue to robust tissues (tendon, bone). The main ambition is to expand their analytical capabilities in the field of deep visual proteomics (DVP) by Mass Spectrometry using a wide range of biological specimens. The instrument will be used for running low to medium scale spatial DVP experiments and implementing single-cell to regional tissue multi-omics experimental workflows and supporting spatial RNA sequencing experiments. Furthermore, cell manipulation or isolation of single-cells in suspension is an future request. The multicolor (>4 filter) options will be applied to protein array scanning at high spatial resolution. The combined system for laser microdissection (MMI CellCut) and Whole Slide Imaging (MMI CellScan) as well as MMI CellRobot is distributed by Molecular Machines and Industries GmbH and is the only versatile LMD system on the market that encompassing all the required features. The MMI CellScan is a cutting-edge whole slide scanner designed to convert any sample format into high-resolution digital data in 5 dimensions. It offers time-lapse imaging for dynamic studies, Z-stack scanning to capture depth, XY scanning for full-slide coverage, and multi-color fluorescence for comprehensive molecular insights. The versability of the CellScan allows imaging of non-tissue speciments such as protein array slides. The MMI CellCut is the most gentle laser microdissection system on the market, designed to protect the surrounding area and preserve the biological integrity of the cut sample. This precision enables reproducible and meaningful results in Deep Visual Proteomics (DVP) experiments and other research applications. The system achieves gentle cutting using a low-energy laser (pulse energy <= 2 µJ), ensuring that tissue remains undamaged. Despite the low energy, the laser operates with a high pulse rate (4 kHz), providing sufficient energy to cut even thicker tissue samples. In addition, the CellCut system offers a serial cutting function for three-point shape and position annotations and a z-drill function that allows wet and thicker tissue areas to be cut step by step with a definable z-step size. This combination delivers the best cutting performance on the market, with a very precise cutting edge of 0.3 µm. Moreover, MMI is the only supplier whose system moves the stage rather than the laser during the cutting procedure. This innovative approach keeps the laser consistently in optimal focus, enhancing cutting efficiency and precision. The MMI CellCut enables leading live cell-cutting ability to culture, dissect and isolate live cells, also in fluorescence mode. In contrast to systems that uses an upright microscope, the MMI laser comes from below, allowing for the dissection of living cells within live-cell chambers or 18-well membrane slides without the need to remove the culture media. This ensures the highest cell integrity for meaningful proteomics applications and re-cultivation. The process is contamination-free, as there is no need to open the culture dish, unlike alternative LMD systems. Additionally, the CellCut LMD system can be combined with a climate chamber offering full environmental control to maintain optimal conditions during the process. Based on a completed market analysis, Aalborg University assesses that, due to the technical reasons mentioned above, only one supplier can meet the total delivery. For those technical reasons, the contract will awarded without prior publication of a tender announcement in accordance with the section §80(3)(2) of the Danish Public Procurement Act. The contract will not be concluded until after expiry of standstill period of 10 calendar days, calculated from the day on which the Direct award preannouncement is Published.
Internal identifier : 2025-132-00690

5.1.1 Purpose

Main nature of the contract : Supplies
Main classification ( cpv ): 38000000 Laboratory, optical and precision equipments (excl. glasses)

5.1.2 Place of performance

Postal address : Niels Jernes Vej 10
Town : Aalborg Øst
Postcode : 9220
Country subdivision (NUTS) : Nordjylland ( DK050 )
Country : Denmark
Additional information :

5.1.6 General information

The procurement is covered by the Government Procurement Agreement (GPA) : yes

5.1.15 Techniques

Framework agreement :
No framework agreement
Information about the dynamic purchasing system :
No dynamic purchase system

5.1.16 Further information, mediation and review

Review organisation : Klagenævnet for Udbud -
Organisation providing more information on the review procedures : Konkurrence- og Forbrugerstyrelsen -
Organisation whose budget is used to pay for the contract : Aalborg Universitet

6. Results

Value of all contracts awarded in this notice : 218 332 Euro
Direct award :
Justification for direct award : The contract can be provided only by a particular economic operator because of an absence of competition for technical reasons
Other justification : AAU SUND is looking to acquire a versatile Laser capture MicroDissection (LMD) system to enable clinical and life science workflows in spatial proteomics, transcriptomics, and multi-omics from cells to robust tissues. The MMI modular concept allows combination with the MMI CellScan (Whole Slide Imaging) and MMI CellDetector (Image Recognition Software). The MMI CellCut combines several proven technologies which enable fast and precise laser microdissection of paraffin fixed and cryo samples, smears and live cell cultures. To dissect areas of interest, MMI employs an ultra precise solid state UV laser while maintaining the samples' morphology and centrifuge tubes without unnecessary induction of physical or chemical forces. The intuitive MMI CellCut software includes several automated functions in a user-friendly design. The simple and comfortable working process with MMI Adhesive Cap technology allows safe and efficient sample isolation with any sample size as well as for positive sample identification. The adhesive Cap technology does not rely on gravity or air streams and thus allows safe collection of samples without the risk of losing the dissected material. A patented PTP Predefined Targeting Positioning, allows easy sample inspection to visualize cell morphology and to confirm sample integrity post laser dissection. Based on a completed market analysis, Aalborg University assesses that, due to the technical reasons mentioned above, only one supplier can meet the total delivery. For those technical reasons, the contract will awarded without prior publication of a tender announcement in accordance with the section §80(3)(2) of the Danish Public Procurement Act. The contract will not be concluded until after expiry of standstill period of 10 calendar days, calculated from the day on which the Direct award preannouncement is Published.

6.1 Result lot ldentifier : LOT-0000

6.1.2 Information about winners

Winner :
Official name : Molecular Machines & Industries GmbH
Tender :
Tender identifier : Molecular Machines & Industries GmbH
Identifier of lot or group of lots : LOT-0000
Contract information :
Identifier of the contract : PLATO Sag 2 LMD system

8. Organisations

8.1 ORG-0001

Official name : Aalborg Universitet
Registration number : 29102384
Postal address : Fredrik Bajers Vej 7K
Town : Aalborg Øst
Postcode : 9220
Country subdivision (NUTS) : Nordjylland ( DK050 )
Country : Denmark
Contact point : Knud Jacob Knudsen
Telephone : 99409508
Roles of this organisation :
Buyer
Organisation whose budget is used to pay for the contract

8.1 ORG-0002

Official name : Klagenævnet for Udbud
Registration number : 37795526
Postal address : Toldboden 2
Town : Viborg
Postcode : 8800
Country subdivision (NUTS) : Vestjylland ( DK041 )
Country : Denmark
Contact point : Klagenævnet for Udbud
Telephone : +45 72405600
Roles of this organisation :
Review organisation

8.1 ORG-0003

Official name : Konkurrence- og Forbrugerstyrelsen
Registration number : 10294819
Postal address : Carl Jacobsens Vej 35
Town : Valby
Postcode : 2500
Country subdivision (NUTS) : Byen København ( DK011 )
Country : Denmark
Contact point : Konkurrence- og Forbrugerstyrelsen
Telephone : +45 41715000
Information exchange endpoint (URL) : https://www.kfst.dk
Roles of this organisation :
Organisation providing more information on the review procedures

8.1 ORG-0004

Official name : Molecular Machines & Industries GmbH
Town : Eching
Postcode : 85386
Country subdivision (NUTS) : München, Landkreis ( DE21H )
Country : Germany
Telephone : +49 89 319 048 40
Roles of this organisation :
Tenderer
Winner of these lots : LOT-0000

8.1 ORG-0005

Official name : Mercell Holding ASA
Registration number : 980921565
Postal address : Askekroken 11
Town : Oslo
Postcode : 0277
Country subdivision (NUTS) : Oslo ( NO081 )
Country : Norway
Contact point : eSender
Telephone : +47 21018800
Fax : +47 21018801
Internet address : http://mercell.com/
Roles of this organisation :
TED eSender
Notice information
Notice identifier/version : 6453bc7c-6285-4c56-92e6-f1d13fa64ef1 - 01
Form type : Direct award preannouncement
Notice type : Voluntary ex-ante transparency notice
Notice dispatch date : 30/01/2025 16:00 +00:00
Notice dispatch date (eSender) : 30/01/2025 16:00 +00:00
Languages in which this notice is officially available : English
Notice publication number : 00071442-2025
OJ S issue number : 23/2025
Publication date : 03/02/2025